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KMID : 1001920100480010008
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Journal of Korean Neurosurgical Society
2010 Volume.48 No. 1 p.8 ~ p.13
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Comparative Analysis of Serum Proteomes of Moyamoya Disease and Normal Controls
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Koh Eun-Jeong
Kim Han-Na
Ma Tian-Ze
Choi Ha-Young
Kwak Yong-Geun
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Abstract
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Objective: The etiology and pathogenesis of moyamoya disease remain unclear. Furthermore, the definitive diagnostic protein-biomarkers for moyamoya disease are still unknown. The present study analyzed serum proteomes from normal controls and moyamoya patients to identify novel serological biomarkers for diagnosing moyamoya disease.
Methods: We compared the two-dimensional electrophoresis patterns of sera from moyamoya disease patients and normal controls and identified the differentially-expressed spots by matrix-assisted laser desorption/ionization-time-of flight mass spectrometry and electrospray ionization quadruple time-of-flight mass spectrometry.
Results: We found and analyzed 22 differently-expressed proteomes. Two proteins were up-regulated. Twenty proteins were down-regulated. Complement C1 inhibitor protein and apolipoprotein C-III showed predominantly changed expressions (complement C1 inhibitor protein averaged a 7.23-fold expression in moyamoya patients as compared to controls, while apolipoprotein C-III averaged a 0.066-fold expression).
Conclusion: Although our study had a small sample size, our proteomic data provide serologic clue proteins for understanding moyamoya disease.
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KEYWORD
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Moyamoya disease, Proteome
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